Signaling via HLA class II molecules : Cell activation and death
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چکیده
منابع مشابه
ULCERATIVE COLITIS AND HLA CLASS II PHENOTYPING IN IRAN
Ulcerative colitis (UC) is a nonspecific acute and chronic inflammatory bowel disease that diffusely involves the colonic mucosa. The etiology of UC has not yet been elucidated fully. However, many studies have found that immunologic disorders may play a role in the pathogenesis of UC. In addition, due to an increased frequency of UC in families, especially an increased monozygotic compared...
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Background: Pulmonary tuberculosis (PT) is one of the endemic diseases in Iraq, and among the suggested predisposing factors are alleles of the human leukocyte antigen (HLA) system. We sought to investigate the association between HLA-class I (A and B) and -class II (DR and DQ) alleles in a sample of PT Iraqi patients.Methods: lymphocytes of 105 PT patients and 40 controls were phenotyped for H...
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This investigation addressed the role of major histocompatibility complex-encoded class I molecules in the activation and proliferation of human lymphocytes. We studied the effect of antibodies specific for HLA-A and HLA-B locus gene products on mitogen-stimulated peripheral blood mononuclear cell (PBMC) subpopulations. Three individually derived, well-characterized anti-HLA class I monoclonal ...
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Human T-cell clones used to define functional epitopes on HLA class II molecules.
Polyclonal reagents have been used to define HLA class II molecules in conventional serologic and cellular typing. We generated human alloreactive T-cell clones to analyze the functional fine specificities of HLA class II molecules that might be important for the phenomenon of HLA and disease association. We chose to examine HLA-Dw14, an HLA-D specificity that has been associated with juvenile ...
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ژورنال
عنوان ژورنال: Major Histocompatibility Complex
سال: 1994
ISSN: 2186-9995,2187-4239
DOI: 10.12667/mhc.1.21